Example:
Original strand : XXXAGCATGCTGCAGTCATGCTTAGGCTAXXXX
First shotgun sequence : XXXAGCATGCTGCAG TCATGCTTAGGCTAXXXX
Second shotgun sequence : TTAGGCTAXXXX XXXAGCATGCTGCAGTCATGC
Reconstructed strand : XXXAGCATGCTGCAGTCATGCTTAGGCTAXXXX
The computational power required to re-align the sequence is enormous. For the shotgun sequencing of the human genome in the Human Genome Project run by [Celera Genomics]? in 2000, several supercomputers were running some month nonstop to align all human DNA correctly.
/talk?