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The active extract of the bark, called salicin?, after the latin name for the white willow (Salix alba), was isolated to its crystaline form in 1828 by [Henri Leroux]?, a French pharmacist, and [Raffaele Piria]?, an ItalyItalian? chemist, then succeeded in splitting it up to obtain the acid in its pure state. Salicin is highly acidic when in a saturated solution with water (pH = 2.4), and is called salicylic acid for that reason. Salicyclic acid's systematic |
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The active extract of the bark, called salicin?, after the latin name for the white willow (Salix alba), was isolated to its crystaline form in 1828 by [Henri Leroux]?, a French pharmacist, and [Raffaele Piria]?, an Italian chemist, then succeeded in splitting it up to obtain the acid in its pure state. Salicin is highly acidic when in a saturated solution with water (pH = 2.4), and is called salicylic acid for that reason. Salicyclic acid's systematic |
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This chemical was also isolated from meadowsweet flowers (latin name spiraea) by German researchers in 1839, and while somewhat effective, also caused many digestive problems including irritated stomach and diarrhea, and can cause death in higher doses. In the 1897, Felix Hoffmann, a chemist working for Friedrich Bayer? & Co, in Germany derivatized one of the hydroxyl functional groups in salicylic acid with an acetyl group (forming the acetyl ester) which greatly reduced the negative effects. The new drug, named a- (for the acetyl group) -spir- (for the flower) -in (a common ending for drugs at the time), had fewer side effects and was more effective than salicin or salacylic acid. This was the first synthetic drug, not a copy of something that existed in nature, and the start of the pharmaceuticals industry. |
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This chemical was also isolated from meadowsweet flowers (latin name spiraea) by German researchers in 1839, and while somewhat effective, also caused many digestive problems including irritated stomach and diarrhea, and can cause death in higher doses. In the 1897, Felix Hoffmann, a chemist working for Friedrich Bayer? & Co, in Germany derivatized one of the hydroxyl functional groups in salicylic acid with an acetyl group (forming the acetyl ester) which greatly reduced the negative effects. The new drug, named a- (for the acetyl group) -spir- (for the flower) -in (a common ending for drugs at the time), had fewer side effects and was more effective than salicin or salicylic acid. This was the first synthetic drug, not a copy of something that existed in nature, and the start of the pharmaceuticals industry. |
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The name "Aspirin" is still a trademark in some countries over a hundred years since its discovery. |
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The name "Aspirin" is still a trademark in some countries over a hundred years since its discovery. However, Bayer lost the trademark in the United States and some other countries as part of World War I reparations. |
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