History of Apoptosis

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	Revision 11 . . (edit) December 9, 2001 4:56 pm by Magnus Manske [wikify]
	Revision 10 . . December 9, 2001 8:56 am by Jaime Gonzalez [Included very short summary of a Perspective by Fesik and Shi (Science, Nov. 16 2001) on latest research in caspases.]
	Revision 9 . . December 1, 2001 3:51 am by Magnus Manske [+biochemical mechanism; add more there!!]
	Revision 8 . . December 1, 2001 3:48 am by Magnus Manske [+prevention of autoimmune reactions]
	Revision 7 . . December 1, 2001 3:42 am by Magnus Manske [Structure, +stuff]
	Revision 6 . . (edit) December 1, 2001 3:16 am by Magnus Manske
	Revision 5 . . (edit) November 24, 2001 4:25 pm by Magnus Manske [wikified last para]
	Revision 4 . . November 24, 2001 9:52 am by Jaime Gonzalez
	Revision 3 . . November 24, 2001 9:47 am by (logged).244.237.xxx
	Revision 2 . . (edit) November 15, 2001 5:11 pm by Magnus Manske [typo, wikify]
	Revision 1 . . November 6, 2001 12:59 am by Magnus Manske [Initial entry]

Difference (from prior major revision) (minor diff, author diff)

Added: 26a27,29

Biochemical execution

Apoptosis is executed by enzymes called caspase?s (see "Controlling the Caspases", by Stephen W. Fesik and Yigong Shi, in Science, Vol. 294, No. 5546, p. 1477, November 16, 2001), which are normally supressed by IAP? (inhibitor of apoptosis) proteins. When a cell receives an apoptotic stimulus, IAP activity is relieved after Smac/DIABLO, a mitochondrial protein, is released into the cytosol.