Class I antiarrhythmics, such as Propafenone hydrochloride or Quinidine, impair the entry of Na+ ions into cardiac cells, slowing the rate of depolarisation and reducing the excitability of the muscle.
Class III antiarrhythmics, based on amiodarone such as Bretylium tosylate or Amiodarone hydrochloride, prolong the effective refractory period, the interval required for re-excitation is increased and arrhythmias are suppressed.