Wikipedia: History of Phenothiazine

Difference (from prior major revision) (minor diff, author diff)

Changed: 1,4c1,59

Phenothiazines are antipsychotic drugs. There are three groups:
*I - Aliphatic compounds have a strong sedative effect, but moderate extrapyramidal and autonomic effects.
*II - Piperidines have moderate sedative effects and fewer extrapyramidal effects than aliphatic compounds, but more autonomic effects.
*III - Piperazines have few sedative effects, pronounced extrapyramidal effects, and less autonomic effects.

Phenothiazines are antipsychotic drugs. There are three groups different by their chemical structure and their pharmacological effects:

Group	Sedative	Extrapyramidal	Autonomic
Aliphatic compounds	strong	moderate	moderate
Piperidines	moderate	weak	strong
Piperazines	weak	strong	weak

	Revision 4 . . (edit) December 11, 2001 6:55 pm by (logged).253.64.xxx
	Revision 3 . . December 11, 2001 6:27 pm by (logged).2.17.xxx [put into table]
	Revision 2 . . December 11, 2001 5:35 am by DavidSaff [Tried for parallelism]
	Revision 1 . . December 11, 2001 5:24 am by TwoOneTwo [stub]