The conjecture is that every simply-connected closed 3-manifold is homeomorphic to a 3-sphere. (See the fundamental group article for a definition of "simply-connected".)
Analogues of the Poincaré Conjecture in dimensions other than 3 can also be formulated. The difficulty of low-dimensional topology is highlighted by the fact these analogues have now all been proved, while the original 3-dimensional version of Poincaré's conjecture remains unsolved. Its solution is central to the problem of classifying 3-manifolds.
External link: