MARCKS proteins (abbreviation of
Myristoylated alanine-rich C-kinase substrate) are proteins
? that play an important role in [cell mobility]
?, secretion
?, [transmembrane transport]
?, and the regulation of the
cell cycle. They are
acidic proteins with a high amount of alanine
?,
glycine, proline
?, and [glutamic acid]
?. They are
membrane-bound by a [lipid anchor]
? at the N-terminus. They are regulated by
Ca2+/calmodulin? and
protein kinase C. In their unphosphorylated form, they bind to actine
? filament
?s, causing them to crosslink.
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