GHB

Gammahydroxy-butyrate (4-Hydroxybutanoic acid, C₄H₈O₃) is a drug, based on a naturally occurring component of mammalian metabolism. It is used most commonly in the form of a chemical salt (Na-GHB or K-GHB). It temporarily inhibits dopamine? release and stimulates pituitary [growth hormone]? (GH) release.

It has been used as a [general anesthetic]?, as a hypnotic in the treatment of insomnia?, but also in the treatment of narcolepsy, by body-builders for its boost to GH release, in the treatment for alcoholism, to aid child-birth, or recreationally as an intoxicant (as GHB, G, Liquid X, Liquid E, GBH, Gamma-oh, Blue Verve).

GHB was first synthesized in the early 1960s by Dr. H. Laborit to use in studying the GABA? neurotransmitter. It quickly found a wide range of uses due to its minimal side effects and controlled action, the only difficulty being the narrow safe dosage range.

Its use recreationally and as a [Date rape]? drug in the 1990s led to it being placed in the US on Schedule I of the Controlled Substances Act in March 2000.